26 of the Rarest Drugs Medical Professionals Had to Administer

‘Sodium thiopental — truth serum’
26 of the Rarest Drugs Medical Professionals Had to Administer

While there are medications we’re all familiar with, like gabapentin or amoxicillin, there are other life-saving remedies so rare they sound straight out of a sci-fi novel.

One Redditor recalled the time he had to administer sodium thiopental for a man who experienced conversion disorder in a movie theater. The patient was brought into the hospital on a gurney — neurologically incapable of bending his knees or snapping out of the psychological stress. When his colleague suggested sodium thiopental, which is a truth serum of sorts, they decided to give it a try. When they administered the drug, they had to talk the patient through remembering that he knew how to use his arms and legs, and coaxed him out of the haze he was under. The Redditor maintains that the entire situation was “the craziest shit” he saw that year. 

Other Redditors of the medical world have disclosed the rarest medications they’ve administered, including wildly expensive Activated Protein C, a poop transplantation and hamster ovaries.

DeBlasioDeBlowMe . 5y ago Botulinum antitoxin. Cost about $15k twenty years ago. The vial came from the CDC and contained four doses. The nurse delivered the first dose and threw the rest away not understanding there were no other single use vials. - 117 ...
GreenMindPhysicians 5y ago Aqueous cocaine. My attending ordered it. I was a third year and too stupid to understand his reason. Still don't know. It looked like water in a fancy beaker when it got to the floor 80 ...
merciless_death 5y ago Edited 5y ago I'm only a pharmacy technician but we had one patient who needed a hydrochloric acid drip, if I remember correctly. I had never seen it before and the pharmacist had to make sure it was in a metal container and delivered via a reinforced line (maybe glass? it was a long time ago). Aside from that, the rarest drug I've actually had to compound has probably been Kcentra (prothrombin complex concentrate) for bleeding. - 93 ...
mixmaster13 5y ago Former pharmacy technician. In our narcotics safe was 1 5ml vial of pure opium tincture. Once a month we would dispense 1ml to a patient who was going through intense chemotherapy. 67 ...
SomeoneLikePoo 5y ago Ex theatre nurse here. There's a rare condition called malignant hyperthermia, which is essentially a severe and life threatening reaction to anaesthetic drugs. The antidote is Dantrolene which is bright orange, expensive AF & kept on site at all times. I'm pretty sure there's a relatively small amount distributed across my state. However since this condition is so rare it often just expires. 43 ...
Plagueiarism 5y ago Melarsoprol for trypanosomiasis (sleeping sickness). Arsenic compound. Was shipped directly from WHO headquarters to us. The patient had to be loaded with prednisolone due to toxicity and we had to remove the peripheral catheter after each dose since it supposedly would react with and destroy the plastic. Totally wild - 149 ...
genaio 0 5y ago I work in cardiac surgery. I've had to give prothrombin complex concentrate to reverse anticoagulation. It's like $6000 per dose. 171 ...
sipsredpepper 5y ago My coworker had to use something called hyularonidase recently. It's given subq when Vancomycin infiltrates in an iv, meaning that it gets out of the vein and starts pooling in the local tissue. Vanco is toxic at high levels and it kills the tissue, so when this happens you have to give multiple small doses of this drug with a tiny needle into the surrounding tissue to break down the vanco and save the tissue. - 173 ...
RosieRN 5y ago Was a traveling nurse in AZ years ago, had a kid stung by a scorpion. They flew in an antidote from NIH they were developing to give to the kid. | didn't give it, the doc did. It was treated like some kind of liquid gold. - 180 ...
athan1214 . 5y ago Probably the hemophiliac medications. There was one that ran in a family, and required a medication to be push IV. 50 mls, 1 q6 seconds. 181 ...
dandandannydandan86 5y ago Synthetic blood. Melbourne, Australia, and I think it was a world first at the time. We had a trauma patient who required a blood transfusion. She couldn't accept blood products however due to her religious beliefs, so synthetic blood was shipped in from the US, ended up saving her life. We hadn't heard of synthetic blood, so it was kinda bizarre. This was a few years ago, so I'm not sure if it's more widely used now but I've not seen it since. - 490 ...
Mike_Carpenter 5y ago | had a wealthy patient who paid $70,000 on his Amex Platinum card for a one month supply of Harvoni (Нер C) for him and his wife. That was not even enough for full treatment. That was the cost every month for 3 months. Не told me he had gotten Нер с from an escort. That is one expensive romp he had! - 425 ...
kawi-bawi-bo 5y ago Some metabolic diseases are extremely rare, but can be treated by replacing whatever enzyme is missing I've prescribed idursulfase for Hunter syndrome. It was something like $250k per month and was covered by the state 432 ...
WhoopDiDiScoop 5y ago By far not a doctor, but a relative of mine had a lot of problem with allergic reactions, especially on the skin, where weird looking welts would form. After about a year of trying out treatments, they eventually used a medication of which the basic component are ovaries of a hamster. They had to repeat giving him those syringes a few times but then it was successfully treated! 338 ...
jareths_tight_pants 5y ago IgG. It's hella expensive and only necessary for certain auto immune issues. I think I gave it for Guillan Barre syndrome but this was like 6 years ago. Each bottle is $20k I think. 320 ...
DocHerb87 5y ago Medical maggots to chew up the dead tissue off a diabetic patient's foot. I was an intern when my attending wanted to use maggots on a patient. The nurses refused to change the dressing and would page me to do it. The pt said he would hear chewing in the middle of the night and that his foot kind of tickled. 914 ...
kilgorevontrouty 5y ago Respiratory therapist. I gave nebulized morphine to a sweet old lady who was dying very painfully in front of her family. There were about 12 of us in the room including me, the PA for to pulmonary group that was covering the icu for the weekend that ordered it and her family. 12 of us in a tiny room. I didn't think about it at the time because I was very concerned about it being out of my scope of practice and because it was the weekend I didn't have a chain of command to really ask.
AlexsSister 5y ago It was many years ago and I was working with end-stage cancer patients. This one woman, who began her treatment outside of the United States, was given a mixture of cocaine, heroin, alcohol, morphine, phenothyazine and some other antiemetics. It was specially made into a liquid and imported from somewhere in Europe. I remember this med so vividly because it's not everyday you give someone heroin. I think it was called something like Bromton Cocktail and the lengths that were gone to to check out and administer a dose of that stuff - we're talking who's got the nuclear
spewgene 5y ago Edited 5y ago Sodium thiopental-truth serum. In residency, someone had a conversion disorder in a movie theater (I know, way back when it was a normal thing to do). The entire place cleared out after the movie, his buddies are talking and realize he's not getting up. Не finally tells them he is paralyzed and can't move. Medics brought him in, he's laying in the gurney in the sitting position, like he's an astronaut. I walk in the room and think to myself, whaaat the fuuuck. I go ahead and take his history, go back and present
HMoney214 0 5y ago NICU nurse here, Ammonul, I've had to give it to two different patients. It's a medication to help with really high blood ammonia levels with kids who have certain metabolic conditions. The medication is extremely expensive! - 1.4K ...
myheartisintheclouds 5y ago Methylene blue. I gave it to a girl who tried overdosing on Orajel. The active ingredient is benzocaine which caused her to develop a methemoglobinemia, treated with the blue drug. It truly is an artificial looking bright blue and I gave it to her in her IV. 2.7K ...
oedisius 5y ago Activated protein C. Can't remember exactly but it was about £50k a dose. Used in severe last ditch sepsis treatment. Not a vial you want to drop. - 2.9K ...
P_tt 5y ago A poop/fecal transplantation. At my first internship during nursing school, there was a patient with a bowel infection caused by clostridium difficile. A few months before he got treated with broad-spectrum antibiotics for a pneumonia, which caused the infection. They tried other treatments to cure the infection, but nothing worked. Eventually, the patient got accepted in a clinic trial for a fecal transplant. One of his kids was the poop donor. After the transplantation the infection actually cleared up! 2.4K ... -
YoYoKepler e 5y ago . Edited 5y ago I had a woman who was on Ziconotide, which is an analgesic derived from Cone Snail venom. If it isn't administered correctly (through the spine), it causes hallucinations. - 4.3K ...
nwbruce 5y ago In 15 years of hospital pharmacy, I've twice had occasion to dispense Thalidomide. It's used as an end-stage anti- nausea med, and comes very carefully packed, with all sorts of warnings about not coming near it if pregnant, and even has little pictures of Thalidomide babies. 7K ...
SugarplumRui 5y ago I once had to administer a certain type of blood product to a patient with a immuneo disorder. Each dose was worth £5K and he needed 3... it also was in a complicated set up. If set it up wrong it would be a waste/unusable. Long story short I administered it okay with the most anxiety I've had in my 6 year nursing career to date. Fun times. 34 ...

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